There is no contraindication to the combination of Gentian Liver Pill and Sanhuang Pill, but it should be used under the guidance of a doctor. Gentian Liver Pill is composed of gentian, chaihu, scutellaria, gardenia, zejiao, mouton and other drugs, with the effect of diarrhea of liver and gallbladder fire, clearing dampness and heat in the lower Jiao. It is mainly used for treating headache, eye redness, darting pain and bitter mouth caused by the inflammation of liver and gallbladder; or urine drenching and yellow odor caused by damp-heat in liver meridian. As this formula is mostly bitter and cold products, it should not be taken for a long time; it should be used with caution for people with weak spleen and stomach. San Huang Wan has the efficacy of diarrhea and detoxification (removing fire, poison and evil qi from the body), and consists of Huang Lian, Da Huang and Scutellaria baicalensis. It is mainly used in the treatment of mouth and tongue sores, sore throat, dry stools, and dysentery due to dampness-heat. Attention, pregnant women should not take it, and people with deficiency of spleen and stomach (weak and cold spleen and stomach) should take it with caution. When discomfort occurs, you should consult a doctor in time and choose medication under the doctor’s guidance, not self-medication.