Uremia with generalized chills is generally considered to be induced by infectious factors, malnutrition, hypotension and hypoglycemia. 1. Infectious factors: uremia patients are often very weak, easy to combine with infections, such as urinary tract infections and upper respiratory tract infections, etc., will cause the body to increase the number of white blood cells and cause the body temperature to rise, resulting in chills and cold symptoms. 2. Malnutrition: patients need to maintain low-salt, low-fat and low-protein diet because of renal failure, patients often combined with nutritional deficiencies, coupled with physical weakness and loss of appetite, can cause chills. 3. Low blood pressure: renal failure will lead to multiple organ damage, combined with heart failure, causing blood pressure and blood volume drop, will also cause chills and cold symptoms. 4. Hypoglycemia: patients with uremia need to undergo dialysis treatment to eliminate toxins and excess water in the body, which will cause a rapid increase in insulin, resulting in hypoglycemia, causing chills and chills. Uremia with generalized chills may also be other causes, please consult the regular hospital in time, further examination, according to the cause, under the guidance of specialists and active treatment.