Chronic urticaria can recur, and in addition to the appearance of red patches and clusters on the skin, it is often accompanied by significant itching, which can significantly affect the patient’s normal life in severe cases. The disease can usually be relieved by active treatment. First of all, chronic urticaria patients often have elevated windy clusters with a smooth, red or pink surface, surrounded by a halo of redness, and can form large, congested, edematous erythema that can appear anywhere on the skin, accompanied by varying degrees of itching, affecting the patient’s sleep. Chronic urticaria is currently difficult to cure and recurrent, seriously affecting the quality of life of patients, who can have anxiety, frustration, and even loss of confidence in treatment. Secondly, angioedema may also occur, mainly in the face, lips, mouth, upper respiratory tract and genitals, with painful swelling of the tissues. The edema appears quickly and usually occurs within minutes and takes several days to get better. If laryngeal edema is present, the patient will experience respiratory distress, and early medical examination is required in critical cases. Finally, chronic urticaria with a generalized attack can cause temporary inflammatory congestion of the mucosal vessels of the skin with massive fluid exudation, resulting in reduced effective blood volume and hypotension, and in severe cases, shock. In addition, patients may also develop systemic symptoms such as abdominal pain, diarrhea, tachycardia, etc. It may also cause respiratory obstruction, wheezing, chest tightness, etc., which should be immediately treated by a doctor.