Urticaria is an allergic disease, but chronic urticaria patients often can not find the allergen, a variety of hospital tests to determine the allergen doctors and patients have doubts, for example, allergen testing said allergic to peanuts, but do not eat peanuts still hives. Some allergens are inevitable for humans, such as dust, pollen, etc. We believe that the appearance of chronic urticaria is related to the weakness of the Wei Qi in Chinese medicine, which is the most external defense of the body. The Chinese medicine identification is called liver depression and spleen deficiency. In recent years, we have been applying Chinese medicine with allergy decoction to regulate the liver and spleen, and the effect is quite good, so we should accumulate more experience in the next step to serve our patients.