Swelling in the palm of the hand can be related to trauma, tenosynovitis, rheumatoid arthritis, deep vein thrombosis of the upper extremity. 1. Trauma: If the palm of the hand suffers a blow or impact and other traumatic injuries, can cause swelling of the palm of the hand can not hold a fist and other symptoms, at this time should go to the hospital in a timely manner to consult the doctor, X-ray film or magnetic resonance to identify the degree of damage and type of injury, to take the appropriate way of treatment. 2. Tenosynovitis: this is common in handicraft workers, athletes, etc., long-term repeated single hand movement. This causes aseptic inflammation of the tendon sheaths in the wrist or finger area, resulting in swelling and inability to make a tight fist. 3. Rheumatoid arthritis: the most common parts of the wrist, metacarpophalangeal joints, proximal interphalangeal joints, joint pain, swelling of the palms of the hands and the inability to grip a fist. 4. Upper extremity deep vein thrombosis: it may be due to thrombosis in the upper extremity, resulting in poor venous return, and then there is swelling of the hand and inability to make a tight fist. Swelling in the palm of the hand can be seen in other causes, it is recommended to consult a doctor in a timely manner, follow the doctor’s instructions to carry out relevant examinations, with the help of the doctor to clarify the cause, and targeted treatment or treatment.