H. pylori quadruplex refers to the use of quadruplex treatment in the eradication of H. pylori treatment. This is a new treatment protocol developed in China based on the national situation, when the eradication rate of killing H. pylori is relatively low. Quadruple sterilization means using a combination of four drugs, including PPI preparations, bismuth preparations, and two antibiotics. The choice of two antibiotics can be made among some of the following antibiotics, such as metronidazole, levofloxacin, clarithromycin, amoxicillin, tetracycline, etc. The choice of antibiotics, on the one hand, depends on whether the patient has a history of drug allergy, for example, amoxicillin cannot be chosen if the penicillin type of allergy is present. In addition, some patients may experience significant gastrointestinal symptoms when taking metronidazole, and care should be taken when choosing it. Some people may experience panic and palpitations with clarithromycin, and clarithromycin, metronidazole, and also levofloxacin, have high resistance rates in some areas, and even metronidazole resistance rates may be as high as 50-70%. Therefore the choice of antibiotics try to use sensitive antibiotics, such as amoxicillin and tetracycline, this type of antibiotic sensitivity is high, kill the eradication rate of H. pylori is also high. So in the clinic to kill H. pylori commonly used in conjunction with a quadruple drug, depending on the specific condition of the patient and the choice.