As the age at surgery for children with congenital heart disease becomes increasingly lower and survival rates significantly higher, the number of children undergoing re-open heart surgery for the treatment of childhood congenital heart disease is increasing year by year in the management of residual or new cardiac malformations as well as in the planning of staged surgeries. The high technical difficulty required for this procedure, which involves avoiding damage to vital cardiac tissues and artificial conduits implanted in previous surgeries, has been implicated as a factor in the significant increase in operative mortality and complications in children. We retrospectively analyzed the clinical data and outcomes of 200 consecutive such children with the aim of improving the diagnosis and treatment of these children. Reoperative cardiac surgery does not increase operative mortality, and we need not fear reoperative cardiac surgery, nor should it be a factor that influences our choice of treatment strategy for our children. However, it is important for us to consider the specifics of each patient undergoing repeat cardiac surgery, and to develop appropriate strategies to anticipate possible MIs, which can help us improve the prognosis of more complex and critically ill patients.