The purpose of vaccination is to prevent the spread of infectious diseases by inoculating the human organism with certain vaccines, vaccines or toxoids. Through the immune response, the organism is made immune to these infectious diseases, so that the chance of contracting them can be avoided or reduced. Vaccination itself does not cause further development of heart malformations, but some reactions of varying severity may occur after certain vaccinations. Generally speaking, local reactions have no effect on heart function, while some systemic reactions (such as fever) may increase the burden on the heart. Therefore, general vaccination is not recommended for children with congenital heart disease whose heart function is usually very poor, especially for children who have frequent heart failure or are in chronic heart failure. However, children who usually have good heart function and good activity endurance can be vaccinated. For children who are preparing for surgical treatment, it is best to avoid vaccination for 1 month before surgery to prevent adverse reactions caused by the low immunity of the body due to surgical blows. Vaccination can be resumed in children after extracorporeal circulation surgery in 3 months after surgery and interventional surgery in 1 month after the recovery of normal heart function. If children who were not vaccinated as planned before surgery due to cardiac function and other problems should complete the missing part according to the vaccination procedure. For children who underwent palliative surgery, if their heart function is still poor after surgery or if heart malformations are still evident, a decision should be made on a case-by-case basis whether or not to perform vaccination. Therefore, the issue of vaccination for children with congenital heart disease must be analyzed on a case-by-case basis, and the view that no vaccination should be given is not correct. The specific indications can be controlled by the staff of vaccination.