Mammary papilloma is a benign tumor, not a serious disease, but has a tendency to become malignant and requires early surgical treatment. Breast papilloma is mostly seen in middle-aged women, mostly occurring in the jugular abdomen of the milk ducts close to the nipple, with thin walls of blood vessels, without conscious symptoms, mainly because of the discovery of bloody nipple overflow. The tumor is small, round, soft and movable, and the nipple can show overflow when the mass is pressed. For solitary ductal papillomas, the entire diseased ductal system should be removed. Accurate preoperative localization is required, with finger pressure to identify the diseased duct, insertion of a syringe needle or injection of methylene blue, and removal of the entire ductal system by making a radial incision after clarification. Prophylactic simple mastectomy may be performed if there is a family history of breast cancer or if papillomas originating in the small milk ducts have a higher chance of malignancy.