Whether glomerular filtration rate 70ml/min can be controlled for 20 years is closely related to the severity of the disease and whether it is actively standardized treatment, etc. If the disease is mild and actively standardized treatment can be controlled for 20 years; if the disease is more severe and not actively standardized treatment, it is difficult to control for 20 years. Generally, there is a big difference between individuals. Patients with glomerular filtration rate of 70ml/min can be seen in acute glomerulonephritis, ureteral stones and other relatively mild condition, and to actively standardize the treatment, glomerular filtration rate can be controlled for 20 years. Patients with glomerular filtration rate of 70ml/min can also be seen in chronic glomerulonephritis, chronic renal failure, diabetic nephropathy and other conditions of the more serious, and at the same time do not actively standardize the diagnosis and treatment, it is very difficult to control 20 years. Usually, there is a big difference between individuals, need to be analyzed on a case-by-case basis. If the glomerular filtration rate decreases, it is recommended that the patient consult a doctor in a timely manner and follow the doctor’s instructions for standardized diagnosis and treatment.