Amoxicillin is generally ineffective for anal fissure, which can be dealt with by conservative treatment and surgical treatment under the guidance of a doctor. Anal fissure is a longitudinal fissure or ulcer of the skin of the anal canal caused by the dryness of the stool, too much force, there can be blood in the stool, periodic pain in the anus during or after defecation, does not belong to the inflammation caused by the disease, so the use of amoxicillin capsules is generally ineffective. 1. Conservative treatment: you can improve the local circulation under the guidance of the doctor in warm salt water sitz bath to relieve sphincter spasm, external nitroglycerin ointment for pain; anal fissure also need to regulate the personal life and diet habits, avoid sedentary, standing for a long time, and less spicy stimulating and oily food, such as onions, ginger, garlic, chili peppers, wine and so on, to keep the bowel movement, to avoid the dryness and knotting of the bowels. 2. Surgical treatment: when conservative treatment has not seen significant improvement, you need to consult the hospital in time, if necessary, you can perform anal fissure excision, anal sphincter part of the incision to achieve the purpose of healing. Please don’t believe in the prescription, the anal fissure, please consult the doctor in time, active treatment, so as not to miss the condition.