After ruling out the corresponding drug contraindications of splenic aminopeptide oral lyophilized powder and prednisone acetate, if the patient’s condition requires, these two drugs can be used in combination. Splenic aminopeptide is a drug made from peptides and nucleotides extracted from fresh porcine or bovine spleen, which belongs to immunomodulatory drugs and has the effect of enhancing the function of body immune cells; prednisone acetate belongs to the class of glucocorticoid drugs and is commonly used in the treatment of allergic and autoimmune diseases, etc. Currently, no drug interactions have been found between these two drugs. If the patient’s condition requires, the two drugs can be used together for treatment after excluding the contraindications of splenic aminopeptide oral lyophilized powder and prednisone acetate. The contraindications of splenic aminotide have not been clarified, and those of prednisone acetate include hypertension, gastric and duodenal ulcers, glaucoma, and myocardial infarction. Adverse reactions to Splenopentin have not been reported. Be careful not to use the drug after a change in its properties. Common adverse reactions to prednisone acetate include infection, Cushing-like syndrome, peptic ulcer, and hypertension. Pay attention to monitoring infection during the use of the drug, and gradually reduce the dosage before discontinuing the drug after long-term use. Splenic aminopeptide oral lyophilized powder and prednisone acetate should be used under the guidance of a physician, and patients are advised to go to the relevant departments of regular hospitals for detailed consultation.