Numbness of limbs aggravated and difficult to cure may be suffering from peripheral neuropathy, multiple peripheral neuritis, cervical spondylosis and other diseases. According to different causes, patients can follow the doctor’s instructions to use general treatment, drug treatment, physical therapy and other ways of treatment. 1. Peripheral neuropathy: If the numbness of the limbs is aggravated and difficult to cure because of peripheral neuropathy, patients can apply local hot compresses; use infrared irradiation and transcutaneous electrical nerve stimulation therapy according to doctor’s instructions; and take nutritive nerve drugs, such as methylcobalamin, etc., to speed up the blood circulation of the limbs and improve the symptoms of numbness of the limbs according to doctor’s instructions. 2. Multiple peripheral neuritis: If the numbness of the limbs is aggravated and difficult to cure due to multiple peripheral neuritis, the patient can take oral nutritional nerve drugs, such as methylcobalamin, etc.; follow the doctor’s instructions to drip thymopeptide, thymosin and other immunomodulators to promote the recovery of the condition. 3. Cervical spondylosis: If cervical spondylosis causes numbness of the limbs to aggravate and difficult to cure, the patient should massage the neck, follow the doctor’s instructions to use ultrashort wave, microwave therapy and other ways to relieve the neck muscle spasm; follow the doctor’s instructions for oral ethylpiperidinone and other muscle relaxants, methylcobalamin and other nutritive nerve drugs for treatment, to alleviate the feeling of numbness in the limbs. It is recommended that patients whose numbness of the limbs is aggravated and difficult to be cured should go to the hospital for relevant examinations to clarify the cause of the disease and then treat the cause.