Recently, a lot of patients from all over the country said that they could not buy Benadryl, and we talked with some overseas patients and learned that the drug is no longer available in some hospitals in Beijing, and it is out of stock in some other cities in China. Some sources said that it is due to the production adjustment of Merck Sharp & Dohme (the manufacturer of Benadryl). As we know, Benadryl is a controlled-release tablet of Cazodopa, which is different from Medopa in that Medopa has a fast onset of action, while Benadryl is a controlled-release tablet, which generally releases the active ingredient within 4-6 hours, with a slower onset of action but longer duration of action than Medopa. The drug is suitable for patients who have end-of-dose phenomenon (drug effect cannot be connected), difficulty in turning over at night, stiffness and poor activity in the morning. So how to face the situation of restorative drugs out of stock, and is there an alternative? In fact, it is understood that all over the country, large hospitals can still prescribe this drug, and it is understood that the manufacturer only later to replace the dosage form, and not to stop production. Even if there is a large area out of stock, it will not take long; 2, the simplest conversion is to replace half a tablet of Xanax with half a tablet of Medopa, but also according to the condition, the dose of Medopa can be increased appropriately if necessary, which needs to be decided after a doctor’s interview; 3, on the basis of existing drugs, consider the combined use of amantadine, Slegiline (such as: Midolpir, Kingspin), etc., can also be combined with receptor agonist-type drugs (such as Tysudar Senfro Rolpinirole, etc.); 4. It should be reminded that the advantages of restorative drugs are certainly long-acting, but there are also disadvantages, such as low drug effectiveness, easy to accumulate in the body, causing allodynia. Finally, I hope that the Pa friends openly face, if they live in the region really out of stock, you can turn to other cities Pa friends, but also to the hospital to find a professional movement disorder experts according to their own condition to adjust the medication.