Knee pain can be caused by physiological and pathologic reasons, and general treatment, drug treatment and surgical treatment are often adopted according to different causes. 1. Physiological causes: knee pain is commonly caused by cold weather, overwork, etc. Generally, conservative treatment is adopted, including keeping warm, avoiding overwork, and using ibuprofen and other medications as prescribed by the doctor to alleviate the pain if necessary. 2. Pathological causes: commonly seen in knee trauma, inflammation, or allergic diseases resulting in symptoms, in addition to taking appropriate pain relief, the application of ceftazidime and other antibiotics, as well as leflunomide and other anti-rheumatic drugs, if necessary, need to carry out the appropriate surgical treatment. Therefore, it is recommended to go to the hospital in time to avoid blindly using drugs to avoid delaying the condition.