Usually, uric acid 420μmol / L ~ 480μmol / L already belongs to the category of hyperuricemia, at this time there is a risk of triggering gout, so it is considered to be more serious. Uric acid is the end product of purine metabolism, mainly by the cell metabolism decomposition of nucleic acids and other purine compounds, as well as food purines by the enzyme decomposition and production. The saturation concentration of uric acid in the body at 37°C is about 420µmol/L. Above this concentration, urate forms crystals that are deposited in a variety of tissues, including the kidneys and synovial membranes of joints, causing tissue damage. Fasting blood uric acid >420µmol/L on two occasions not on the same day is currently defined as hyperuricemia. Therefore, uric acid 420 µmol/L to 480 µmol/L usually falls into the category of hyperuricemia. Some hyperuricemia can develop into gout, so uric acid 420μmol/L~480μmol/L is more serious. Uric acid 420μmol / L ~ 480μmol / L, generally need to adjust the diet structure, try to avoid eating animal offal, seafood, broth and beer, fruit juice and other high-purine food, daily can be moderate and drink more water, if necessary, can follow the doctor’s instructions to use sodium bicarbonate and other drugs to alkalinize the urine, in order to improve the condition. If you find uric acid 420 μmol / L ~ 480 μmol / L, you need to consult a doctor in a timely manner, follow the doctor’s instructions to standardize the diagnosis and treatment, in order to avoid the occurrence of gout, kidney injury and other adverse consequences.