As Parkinson’s disease is a degenerative disease of the central nervous system, the disease slowly progresses and worsens, in order to improve the patient’s symptoms and improve the quality of life, patients need to take medication every day, of which levodopa drugs as the basic drugs for Parkinson’s disease patients, long-term use, patients are most worried about the side effects of drugs, so what side effects can occur when taking levodopa drugs for Parkinson’s disease? Recent side effects are common: 1. Gastrointestinal reactions: mainly manifested as nausea, vomiting, anorexia and constipation. The appearance of these symptoms is obviously dose-dependent, and the higher the dose, the more obvious the side effects. Therefore, when you start taking levodopa drugs, you should start with a small dose and increase the dose slowly and gradually, or take a smaller dose each time and increase the number of times you take it. 2, cardiovascular side effects: such as upright hypotension, arrhythmia. Upright hypotension is characterized by dizziness when changing position, such as when standing up from a sitting position. It usually occurs in patients who have just started taking levodopa drugs and disappears after several weeks and months. A small number of patients may have symptoms of panic and tachycardia, and the drug should be discontinued in severe cases. 3. Sleep disorders and psychiatric symptoms: Some patients may experience increased sleep or insomnia, but they mostly do not affect the treatment. A small number of patients develop mild mental confusion one hour after taking the drug. A few other patients develop severe psychiatric symptoms, anxiety, delusions, hallucinations, etc. This phenomenon often occurs after dusk, and these symptoms can be reduced and disappear after reducing the levodopa dose or discontinuing the drug. Long-term side effects mostly occur after 3-5 years of taking the drug: 1. Heterokinesia, i.e., patients develop involuntary hand and foot movements, which are manifested by involuntary head and facial twitching, pouting, tongue turning in the mouth, as well as shrugging shoulders and hand and foot movements of the limbs. If the patient takes a higher dose, it may appear shortly after taking the drug. This phenomenon occurs mainly when the symptoms improve most after each dose and is called peak dose isokinetic disorder. This phenomenon can be alleviated by reducing the dose per dose, or by switching to a long-acting extended-release, or controlled-release dosage form. Another phenomenon is that the isokinetic disorder appears before each dose and after the efficacy of this dose is reduced, known as bidirectional isokinetic disorder, which may require an increase in drug dose or surgical treatment. 2, motor fluctuations, one is the end-of-dose phenomenon. It occurs mostly after 3-5 years of levodopa application, and is manifested as a shortening of the effective time after each dose and an aggravation of Parkinson’s disease symptoms in the phase before the next dose. This phenomenon is predictable. Another phenomenon is the “on-off” phenomenon. This phenomenon occurs after several years of medication and is unpredictable, and is not related to the duration of medication. 3.Morning stiffness, manifesting as worsening of symptoms and difficulty in movement when waking up in the morning. 4. Delayed onset of action, which is manifested by a longer time to appear after taking the medication than before, often associated with impaired gastric emptying and the effects of diet. Patients with Parkinson’s disease need to take long-term medication to control the disease, levodopa drugs as the basic medication, has a very good effect, but because many patients have a one-sided understanding of the side effects of the drug, irregular medication. After careful understanding, it can help patients to prevent, actively cooperate with the doctor’s treatment, take the medication regularly, and consult the doctor in time if there are problems, so that some side effects can be avoided.