Recently, many patients have asked me questions about pregnancy in women with SLE, both in the clinic and on the internet. Today, I will give a brief answer to some of your concerns. 1, the selection timing of pregnancy in patients with systemic lupus erythematosus (SLE): ① the disease is stable for more than 1 year; ② 24-hour urine protein is less than 0.5g; ③ daily glucocorticoid is less than 10mg (prednisone and equivalent dose); ④ no oral immunosuppressants other than hydroxychloroquine. 2, SLE pregnancy monitoring time: ① first 20 weeks of pregnancy, follow-up every 4-6 weeks; 20-28 weeks, follow-up every 2 weeks; 28 weeks to delivery, follow-up every 1 week. 3, SLE pregnancy monitoring content: ① symptoms: rash, joint pain, hair loss, oral ulcers; ② laboratory tests: blood and urine routine, liver and kidney function, blood glucose, dsDNA, complement, CRP. dsDNA is elevated, complement is decreased, CRP is elevated not only indicates SLE activity, but also signals the occurrence of preterm delivery of the fetus. ③Fetal cardiac ultrasound should be checked at 16-24 weeks of gestation, together with monitoring PR interval of fetal ECG for early detection of cardiac abnormalities of fetal AV block, and fetal cardiac ultrasound should be done every 2 weeks at 26-32 weeks to monitor PR interval changes. 4. Pharmacological treatment of SLE activity during pregnancy: ① Pain: acetaminophen can be used safely, NSAIDS can only be used between 3 and 7 months of pregnancy. ②Hormones: If the condition requires the use of glucocorticoids then choose hormone therapy that cannot pass through the placenta and does not contain fluoride. ③Immunosuppressants: Hydroxychloroquine (HCQ) and azathioprine (AZA) are available, while cyclosporine, cyclophosphamide, motilmic acid, methotrexate, and leflunomide are used with caution. 5, SLE pregnancy combined with APS (secondary antiphospholipid antibody syndrome) treatment: ① ACA (anti-cardiolipin antibody) positive without thrombosis and history of miscarriage, stillbirth, after pregnancy can be treated with a small dose of aspirin; ② history of thrombosis before pregnancy with warfarin, to be replaced by heparin therapy after pregnancy until 8 hours before delivery or cesarean section; ③ high titer ACA, with a history of adverse pregnancy and thrombosis (iii) those with high titers of ACA and a history of adverse pregnancy and thrombosis may be treated with low-dose aspirin combined with heparin until 8 hours prior to delivery or cesarean section after pregnancy. Low-molecular heparin has fewer side effects in reducing PLT, and only one injection is needed daily, so it is more recommended by domestic and foreign scholars.