Osteoarthritis early squatting and standing up or running stairs when both knees are sore and weak slowly before evolving into pain, swelling, deformity and functional impairment. The pain of osteoarthritis of the knee is significantly different from other pains: in terms of degree, it is due to prolonged walking, soreness and discomfort after squatting, gradually developing into pain when walking, which can be stopped by medication and partially affects daily life. Finally it becomes severe pain, which seriously affects daily life and sleep, and the knee joint cannot be extended and flexed and moved. Pain characteristics: (1) Activity pain: The pain is caused when the knee joint is in a stationary position for a long time and then starts to change position, which is reduced after activity and aggravated when there is more weight bearing and activity. (2) Weight-bearing pain: People with knee problems may often feel no pain in the knee when riding a bicycle or swimming, but pain when going up and down stairs, going up and down slopes, sitting and squatting and standing up, and increased pain when carrying heavy objects, which is mainly caused by increasing the load on the knee joint, such as taking a long bus ride or watching a movie when the seat restriction forces the knee to bend. This is mainly caused by increased load on the knee joint, such as a long bus ride or a movie where the seat is restricted and the knee is forced to bend. (3) Active activity pain and passive activity light, active activity muscle contraction increase joint load. (4) Pain at rest: pain when the knee joint is at rest for a long time or when sleeping at night, which is mainly due to poor venous return and increased pressure in the medullary cavity and joint. (5) “Old cold leg”: Another characteristic is that it is aggravated in autumn and winter, and it is aggravated when the weather changes, so many people also call it “old cold leg” and “weather station”. (6) Swelling is another important manifestation of osteoarthritis of the knee joint: this is caused by two factors: on the one hand, the synovial membrane and the joint capsule of the joint are stimulated by the detached cartilage fragments in the late stage of the disease and become congested, edematous, hyperplastic, hypertrophic, with increased synovial fluid, resulting in synovitis and joint effusion. On the other hand, hypertrophy of the hyperplastic synovial membrane, enlargement of the fat pad, osteophytes, and formation of bone redundancy are caused. (7) Deformity: inversion of the knee is predominant, which is associated with round and convex inner femoral ankle, while the tibial plateau is depressed, relatively loose bone, weak medial meniscus, and in some cases, internal rotation of the lower leg. The deformity makes the load more uneven and the deformity more severe. The other is due to malalignment of the patellar force line, or enlargement of the patella. The medial femoral muscle atrophies, the uneven pulling force of the medial and lateral patella, and the strong lateral support band pulling the patella make the patella move outward, and the patella grows. Dysfunction: The knee joint is the center of lower extremity movement, and its function is to move and support weight-bearing. When the degeneration of the knee joint reaches a certain level, its function will be significantly affected, such as feeling a kneeling sensation with knee weakness. This is especially prominent when walking up and down stairs, which is mainly due to the damage of the cartilage surface, the unevenness of the joint surface, the atrophy of the quadriceps muscle, and the destruction of the joint stabilization system. (8) Popping sound: mainly from two causes: one is the inflammatory exudation of tendons or peritendinous tissues at the joint, producing friction sounds. On the other hand, it comes from within the joint: large cartilage defects, meniscal rupture and free body entrapment in the joint space caused by sliding back and forth when moving. (9) Interlocking: 1 gram sex is due to large free body or meniscus (rupture) caught in the middle of two joints, is a joint protrusion severe pain, easy to fall, the joint can not extend and flex, weight bearing. In pseudo, the synovial crease grows into between the two bones. Frequent gram positive interlocking, undoubtedly damage the cartilage surface of the joint. Weakness of movement: joint stiffness: refers to resting a certain position and then moving inflexibly. (10) Instability: weakened stabilizing power of postural support such as quadriceps atrophy, lateral instability, gait swaying (repeated swelling of the joint, more fluid accumulation, joint laxity). (11) Reduced range of motion in joint flexion and extension: the joint is often swollen and forced to increase intracavitary volume when in a mildly flexed position. Over time, peripheral muscle spasm tends to occur and movement is limited. And accompanied by a decrease in knee muscle strength, joint capsule atrophy, bone growth, patellar mobility reduction, proliferation of adhesions caused. And joint straightening is not possible.