Weakness of fist after cerebral infarction may be due to clinical symptoms after cerebral ischemia or sequelae of cerebral infarction. Cerebral infarction, also known as ischemic stroke, has atherosclerosis, cardiogenic embolism, small artery occlusion as its main etiology. Due to the reduction of blood supply or interruption of blood flow, it can lead to ischemia of cerebral tissues, causing a variety of clinical manifestations. For example, when middle cerebral artery occlusion is caused, it can cause contralateral central hemiparesis with numbness and weakness of limbs, as well as manifestations such as poor speech or sensory impairment, so there can be a feeling of powerlessness when clenching fists. If after the onset of cerebral infarction and treatment, there are still cases of limb weakness and numbness as sequelae of cerebral infarction, it is necessary to insist on exercising and preventing the recurrence of cerebral infarction to improve the symptoms in time. After discovering cerebral infarction, we should seek medical treatment immediately to save lives, and timely symptomatic treatment to improve cerebral circulation and prevent recurrence.