There are generally no topical creams for syphilis in the lower body of men. There is no specific difference between the medication used to treat syphilis infection in men and women, and the main treatment medication is penicillin. Syphilis is a sexually transmitted disease caused by the syphilis spirochete, mainly through sexual transmission, mother-to-child and blood transmission. Syphilis is divided into three stages, and patients with syphilis who are not treated in time can experience damage to tissues and organs throughout the body within 1 to 2 years after infection. For example, cardiovascular and cerebrovascular lesions, musculoskeletal destruction. The preferred treatment for syphilis is penicillin therapy, with no topical ointment. Different penicillin treatment regimens and courses are used according to the stage of syphilis. Commonly used drugs include benzylpenicillin, procaine penicillin G, and aqueous penicillin, which are effective in inhibiting the syphilis spirochete. If you are allergic to penicillin, drugs such as doxycycline and ceftriaxone sodium are also available. If you have syphilis infection, it is recommended to go to the hospital in time, and standardize the treatment with the help of the doctor, so as not to delay the condition. The above medications need to be used under the guidance of a doctor.