Painless breast lump is the most common first symptom of breast cancer. Most of the lumps are located in the upper outer quadrant and are usually single lesions with hard texture, unclear borders, unsmooth surface, no pressure pain and poor mobility (in advanced stage, they can be completely fixed on the chest wall). The mass has a tendency to gradually increase in size. 2. Skin changes 1. Dimple sign: When the tumor invades Cooper’s ligament, the ligament will shorten and cause the skin to be sunken. 2.Orange peel-like changes: When the subcutaneous lymphatic vessels are blocked by cancer cells, the lymphatic flow obstruction leads to skin edema and hair follicle invagination, resulting in “orange peel syndrome”. 3.Satellite nodules in skin: When the cancer cells entering the subcutaneous lymphatic vessels form metastatic nodules alone, multiple nodules can be seen around the primary foci, which is clinically called “satellite sign”. 4. Skin invasion and ulceration: When the tumor invades the skin, it may appear red or dark red-like changes. When the tumor continues to increase, local ischemia and ulceration may become cauliflower-like changes, which is called “cauliflower sign”. 5. Inflammation-like changes: When the cancer cells spread to the subcutaneous lymphatic network, it leads to cancerous lymphangitis, which is characterized by congestion, redness and swelling of the whole breast skin, and increased local skin temperature, resembling inflammation, but the systemic symptoms of pain and fever are not obvious, which is clinically called “inflammatory breast cancer”, and we can call it “inflammation sign”. We can call it “inflammatory sign”. This type of breast cancer is commonly seen during pregnancy and lactation. Nipple change 1. Nipple retraction and distortion: Mostly due to tumor invasion of the tissue below the nipple. Nipple overflow (mostly blood): often caused by papillary carcinoma in the large duct or tumor invasion of the large duct. 3.Eczema-like changes: It is a unique manifestation of eczema-like carcinoma (Paget’s disease) with special performance. It can be seen clinically as areola and nipple erosion, crusting, oozing and flaking, which is similar to eczema. 4. Regional lymph node enlargement The lymph node enlargement in the ipsilateral axilla may be single or multiple, initially active, then may fuse with each other or adhere to the surrounding tissues. As the disease progresses, the ipsilateral supraclavicular lymph nodes may also become enlarged one after another. It is worth noting that very few breast cancer patients only show enlarged lymph nodes in the armpit but no breast lump can be felt, which is called occult breast cancer. 5.Distant metastasis Advanced breast cancer can spread to all tissues or organs. The common sites of metastasis are bone, lung, pleura, liver, brain and local recurrence, and produce corresponding symptoms. In conclusion, once abnormal breast manifestations are detected, you should take the initiative to go to the hospital for professional examination by a doctor. When diagnosed with breast cancer and receiving other anti-cancer treatments, attention should be paid to the early detection of metastatic signs. Whether it is early or late stage, early detection of changes in the disease is a very necessary prerequisite for striving for effective treatment.