Patients with leukemia may have severe pain all over the body. The pain of leukemia patients is mainly manifested as bone pain, which is caused by the excessive growth rate of leukemia cells and the increased pressure in the bone marrow cavity, and leukemia is a blood disease that can have extramedullary invasion, so it is possible for leukemia patients to have pain all over the body. Leukemia is a class of malignant clonal disease of hematopoietic stem cells. Clonal leukemia cells will accumulate and infiltrate in the bone marrow and other hematopoietic tissues due to differentiation disorders, uncontrolled proliferation and other reasons, and at the same time inhibit normal hematopoietic function. Clinical symptoms include anemia and bone pain of varying degrees. When leukemia patients have symptoms of generalized pain, it is recommended to go to the hospital in time to determine the cause of the disease and then give targeted treatment under the guidance of physicians.