High-risk type 52 positive refers to human papilloma virus type 52 infection of the body’s skin or mucous membrane, causing squamous epithelial proliferation and resulting in the occurrence of a variety of symptoms. Infection without symptoms usually does not require special treatment, but with certain symptoms should be promptly seen. HPV type 52 infection without abnormal symptoms usually does not require special treatment. Maintaining a happy mood, strengthening nutrition, and exercising may prevent further infection by resisting the virus through one’s own immunity. However, it is recommended to have a recheck every six months until it turns negative. If after two years, HPV52 is still persistently positive and some clinical symptoms appear, such as gray-brown, brown or normal skin color with rough surface papules; flat papules of soy size on the face and back of hands; papules and keratotic plaques around the genitals; virus invades the throat and symptoms such as hoarseness and difficulty in breathing should be promptly treated by a doctor. In the case of skin lesions, topical treatment with drugs, such as retinoic acid, fluorouracil, alpha-interferon, etc., is usually taken, and the choice of drugs should be used under the guidance of a doctor. For laryngeal papilloma caused by viral invasion of the pharynx, epithelial lesions of the genital tract with a high cancer rate, and warts that cannot be treated conservatively, surgical treatment is recommended.