What are anti-sperm antibodies? Anti-sperm antibodies are a complex pathological product that can affect both men and women, and their exact cause is not fully understood. What exactly are antisperm antibodies? The sperm and seminal plasma of men are specific antigens for women, and when they come into contact with the blood, both men and women can have an immune response and produce the corresponding antibodies, which are called anti-sperm antibodies! What is a positive anti-sperm antibody? Anti-sperm antibodies are positive, it is due to the destruction of the blood-testis barrier by physical, chemical and biological factors, while the sperm antigen is leaking out, mononuclear phagocytes enter the testes and epididymis, engulf the sperm, and pass the sperm antigen to T or B lymphocytes, generating humoral and cellular immune responses, thus generating anti-sperm autoimmunity. Anti-sperm antibodies can be produced in both men and women. Being positive for antisperm antibodies means that they kill, phagocytose, agglutinate and brake sperm. (i.e. they are slaughtering your tadpoles!) What are the signs of positive antisperm antibodies? Positive antisperm antibodies are difficult to detect and the patient himself has no particular discomfort. In men, it is often detected during systematic examination when sperm quality decreases, vitality decreases, viability is not up to standard, or even a large number of abnormal sperm appear. Women may suffer from infertility, poor embryo development or early miscarriage as a result. What are the dangers of positive anti-sperm antibodies? 1.Interference with spermatogenesis, resulting in no sperm or few sperm. 2, Antibodies combine with sperm and inhibit sperm from running in the male reproductive tract. 3.Ejected sperm agglutinate themselves. 4, Sperm are braked in the female reproductive tract and are phagocytosed by macrophages and induce female immunity to sperm. 5.Sperm cannot cross the cervical mucus. 6.Interference with the recognition and fertilization of sperm and egg. 7.Interference with sperm capacitation and acrosome reaction. 8. Interference with the early development of the embryo after fertilization. In short: it can affect pregnancy! Affects pregnancy! Affects pregnancy! What is the treatment for positive antisperm antibodies? Anti-sperm antibodies are a common factor causing infertility, and we treat them for fertility purposes. Commonly used treatments include corticosteroid inhibitors, semen washing, intrauterine insemination (IUI), in vitro fertilization-embryo suppression (IVF-ET) and intracytoplasmic single sperm injection (ICSI) of the egg. 1.Isolation therapy: Use condoms during sexual intercourse to keep semen away from the female reproductive tract and no longer produce new anti-sperm antibodies, thus allowing the anti-sperm antibodies in the body to be gradually discharged from the body and the concentration to decrease, no longer causing braking and agglutination of sperm for therapeutic purposes. 2. Immunosuppressive therapy: Adrenocorticosteroid drugs can be used to treat immune infertility, with a conception rate of between 20% and 45%. A series of side effects may occur with immunosuppressive therapy, so it is recommended to use them with caution. 3, Chinese medicine evidence-based therapy: after clinical exploration and summary, Chinese medicine has accumulated a lot of experience in the treatment of immune infertility and has certain advantages. Commonly used are nourishing Yin and tonifying the kidneys, clearing heat and detoxification, invigorating blood and eliminating blood stasis, relieving dampness and eliminating phlegm, and so on.