For Helicobacter pylori infection, the current clinical practice of quadruple drug therapy is the best treatment. The specific drug selection is determined by the doctor according to the patient’s condition. Quadruple drugs mainly include proton pump inhibitors, two antibiotics, bismuth. 1. Proton pump inhibitor: generally refers to esomeprazole, lansoprazole, rabeprazole, can choose one of them. 2. Two kinds of antibiotics: There are more kinds of antibiotics in the clinic, such as amoxicillin, metronidazole, tetracycline, levofloxacin, clarithromycin, furazolidone and so on. The doctor will choose two antibiotics according to the patient’s specific situation. If some patients have an allergic reaction to penicillin, they should avoid amoxicillin. In addition, metronidazole and clarithromycin should also be avoided, otherwise it is easy to cause gastrointestinal reactions, such as nausea, vomiting and other adverse symptoms. 3. Bismuth: Bismuth is mostly pectinized bismuth in the clinic. Some patients who have taken bismuth will have black stools. Some patients who have taken clarithromycin will have bitter mouth, astringent mouth and other symptoms. This series of reactions is a normal drug reaction, do not worry too much. To treat Helicobacter pylori infection, please follow the doctor’s instructions for medication and regular review.