Melatonin is not very harmful to the stomach, melatonin is a hormone-like substance secreted by the normal pineal gland to help sleep and regulate mood. Normal human secretion of melatonin are enough, but when with age, the pineal gland will gradually shrink, some older people lack of melatonin, and lead to chronic insomnia, at this time to take melatonin as well as melatonin-related receptor agonists, such as Agomelatine, etc. is more suitable, and safer. Melatonin toxic side effects are very small, also does not exclude a very few people after taking, there are gastrointestinal reactions, probably in the drug about 2-3 weeks, the symptoms naturally disappear, there are some patients taking melatonin, always feel particularly uncomfortable in the stomach, heartburn, uncomfortable, at this time are not necessarily melatonin, may also be some patients in addition to insomnia, there are also serious anxiety and somatization disorders, so the drug is in a hypersensitive state, at this time is not necessarily all melatonin lead to, and so The drug is in a hypersensitive state, at this time may need to combine the use of other digestive, improve gastrointestinal symptoms of the drug, including some other anxiolytic drugs, for insomnia is better, the toxic side effects are also smaller, the patient’s compliance is also better.