The method of H. pylori eradication is a quadruple regimen containing bismuth, i.e., a proton pump inhibitor + 2 antibiotics + 1 bismuth. It should be noted that the eradication rate of quadruple therapy is not 100%, and there is a possibility of eradication failure. Helicobacter pylori enters the stomach through the mouth and settles in the gastric mucosa, which mainly causes chronic gastritis, gastric ulcer, duodenal ulcer and other diseases after infection. Clinically, a quadruple regimen is generally recommended, such as omeprazole, clarithromycin, amoxicillin, and bismuth potassium citrate used in conjunction. The course of treatment lasts 10 to 14 days for complete eradication of H. pylori and is usually reviewed 4 weeks after stopping the medication. Eradication failure is recommended to change the treatment program under the guidance of the doctor. In daily life, patients with H. pylori infection should pay attention to personal hygiene, quit smoking and limit alcohol, choose a light and easy-to-digest diet, avoid stimulating diet. Avoid sharing tableware and kissing with H. pylori infected people to avoid being infected. It is recommended that patients diagnosed with H. pylori infection go to the hospital in a timely manner.