Mupirocin ointment is a commonly used antibiotic ointment in clinical practice. Mupirocin ointment can be applied to the face, especially when an infection occurs on the face, and can play a good role in fighting the infection. Not all facial diseases can be treated with topical application of mupirocin ointment, such as acne. For patients with acne that is not very serious, antibiotic ointment is not the first choice of medication that can be used for treatment; even if acne has co-infection occurring, only topical application of mupirocin ointment is needed, not the whole face. Many patients have the misconception that antibiotics such as mupirocin can be applied to the entire face.