The causes of high glutamate dehydrogenase include long-term alcohol consumption, drug factors and liver diseases, which need to be analyzed specifically. 1. Long-term alcohol consumption: If patients drink alcohol for a long time, it may lead to liver cell damage or even cause alcoholic hepatitis, which in turn leads to the phenomenon of high glutamate dehydrogenase. If patients have long-term alcohol consumption, they should quit drinking in time, which can effectively alleviate the situation, and high glutamate dehydrogenase can gradually return to normal. 2. Drugs: If patients take lipid-lowering drugs or analgesic drugs, such as simvastatin tablets and acetaminophen tablets for a long time, it can cause liver damage, which will lead to high glutamate dehydrogenase. You can go to a specialized hospital for consultation and stop using such drugs as prescribed by the doctor to avoid further liver damage. 3. Liver disease: Glutamate dehydrogenase mainly exists in the mitochondria of the liver, if liver diseases such as chronic hepatitis, acute hepatitis, cirrhosis, etc., cause substantial lesions in the liver cells, resulting in mitochondrial damage, which leads to the occurrence of high glutamate dehydrogenase. Liver disease should be actively treated. Patients are advised to develop good living habits in general and avoid excessive drinking for a long time. If liver disease exists, patients should go to professional hospitals for consultation and further examination and treatment under the guidance of doctors.