Barrett’s esophagus, a pathology in which the squamous epithelium of the lower esophagus is covered by the columnar epithelium of the stomach, may be associated with reflux esophagitis. The etiology of Barrett’s esophagus is still not fully understood, and it is currently thought that it may be related to reflux esophagitis. This is so because 10% of patients with gastroesophageal reflux (GERD) develop Barrett’s esophagus, whereas 90% of patients do not undergo changes. Diagnosis of the disease can be made by gastroscopy of the mucosal lesions in the lower esophagus and can also be confirmed by biopsy.Treatment of Barrett’s esophagus includes medication, endoscopic treatment, and surgical intervention. Patients should seek medical attention if they have any discomfort, and should be followed up regularly for dynamic observation and prevention of cancerous changes.