The late stage of pneumoconiosis mainly involves comprehensive treatment according to the needs of the disease, active prevention and treatment of comorbidities/complications, alleviation of clinical symptoms, slowing down the progress of the disease, prolonging the life span of the patients, and improving the quality of life of the patients. Pneumoconiosis is a disease characterized by diffuse fibrosis of lung tissue caused by long-term inhalation of productive mineral dust and its retention in the lungs during occupational activities. In the advanced stage, the main manifestations are recurrent coughing and sputum, chest pain, and dyspnea after activity and even at rest. There is no special treatment for the late stage of pneumoconiosis, which can be treated by anti-fibrotic treatment with drugs such as hanpengi methylin tablets, pirfenidone, etc., asthmatic treatment with drugs such as salbutamol, aminophylline, etc., and cough-suppressing treatment with codeine, dextromethorphan, and nalcodone. If there are complications such as tuberculosis, active anti-tuberculosis treatment is needed to treat the complications. If the diagnosis of pneumoconiosis is confirmed, it is recommended to consult a regular hospital in time, complete the examination and follow the doctor’s instructions for standardized treatment. Pneumoconiosis patients should quit smoking, avoid living dust contact, strengthen nutrition and develop healthy and good living habits.