Blisters in medicine refers to blisters, being bitten by fleas is generally known as insect bite reaction in medicine, after the emergence of insect bite reaction puncture blisters first need to observe their own situation, and then take general treatment, medication and other ways to deal with. If the insect bite reaction patients puncture the blister on the skin out of water, first need to observe the local situation, if there is no abnormal situation, need to keep the local clean, to avoid the outflow of water infection of other parts. If there are abnormalities, such as itching and worsening symptoms, patients need to follow the doctor’s instructions to take oral antihistamines, such as loratadine, cetirizine, etc., which can reduce inflammation and promote recovery. If secondary infection occurs, also need to follow the doctor’s prescription oral antibiotic drugs, such as ceftazidime, cefuroxime and so on. If the patient punctures the blister by himself and appears to be out of the water, it is necessary to observe the local symptoms, and it is recommended to go to a regular hospital, and cooperate with the doctor to carry out standardized treatment.