Cold and pain in the limbs, weakness usually have two major factors: First, from the perspective of Chinese medicine identification belongs to the wind and cold evil invasion of the body, in the body of the basic immune deficiency will lead to cold extremities, fatigue and pain in the body, weakness of the symptoms, which belongs to the wind-cold cold and rheumatism bone disease of the typical clinical symptoms. Secondly, from the perspective of Western medicine, the cold, pain and weakness of the limbs usually have the following reasons: 1, belonging to the initial symptoms of viral colds, viral colds, the body’s heat-sensitive nerves to adjust the point of downward shift, thus excluding the role of immune microorganisms and the effect of self-consciousness of the limbs by the cold cold. 2, in the early stage of the infection in the acute gastroenteritis, there will be the symptoms of the extremities by the cold, pain, weakness. 3, some infectious shock and the early stage of the infection in the early stage of the infection in the early stage of the cold, pain, weakness. 4, In the early stage of certain infectious shock and hypovolemic shock, traumatic shock, distributional shock, there will also be cold extremities, wet, pale skin, wet and cold, rapid pulse, weakness, etc. 4, the early symptoms of hypoglycemic reaction and hypoglycemic coma will also appear cold extremities, weakness.