Small blisters on the lips may be caused by diseases such as herpes simplex of the mouth and lips, desquamative labialgia, hand, foot and mouth disease, etc. Ointments such as acyclovir, tretinoin, or medications such as interferon alpha need to be used to address the cause. If the small blisters on the mouth are caused by herpes simplex on the lips and mouth, the patient needs to use antiviral ointments such as 3% acyclovir ointment, 1% penciclovir cream, etc. under the guidance of the doctor. If the small blisters on the lips are caused by desquamative lipitis, patients need to follow the doctor’s instructions to use topical tretinoin, dexamethasone and other glucocorticoid ointment, or gentamycin, mupirocin and other antibiotic ointment. However, if it is due to hand-foot-mouth disease, interferon alpha sprays can be used in the early stages of the disease as prescribed by the doctor. It is recommended that patients with small blisters on the lips go to the hospital for consultation to clarify the specific cause of the disease, cooperate with the doctor to actively treat the primary disease, and strengthen the management of daily life.