Schistosomiasis is a disease caused by schistosome parasites in the human body. If it belongs to the acute stage or the early chronic stage with a relatively short course of treatment, it can be cured; however, if it belongs to the late chronic stage, its condition is complicated and serious, and the cure rate is relatively low. If the disease belongs to the acute stage or chronic early schistosomiasis, the course of the disease is relatively short, the condition is relatively mild, the symptoms are not obvious, there are no relevant complications, after regular treatment, most patients can be cured, and it is not easy to leave complications. However, if it belongs to the chronic advanced stage, and the condition is more serious, the disease duration is relatively long, easy to cause hepatic coma, hepatic necrosis or ascites failure, etc., generally can not be completely cured, and the healing process is very poor. After the diagnosis of schistosomiasis, we should consult the doctor as soon as possible, and timely targeted treatment, including supportive therapy, symptomatic treatment, and so on, specific should follow the doctor’s instructions for reasonable use of drugs. For those with upper gastrointestinal bleeding and hypersplenism, surgical treatment should be taken under the guidance of physicians.