Clarithromycin is effective in the treatment of acne, but is generally not the drug of choice in clinical practice. Clarithromycin belongs to a class of macrolide antibiotics that have antibacterial effects, so it can also treat acne and kill Propionibacterium acnes, but it’s not generally the drug of choice in the clinic. The best antibiotics for treating acne are tetracycline antibiotics, the most commonly used being memantine, or minocycline. In addition, there are many aspects in the development of acne, and P. acnes infection is only one of them. Other aspects include exuberant sebaceous gland secretion, high androgen levels, and abnormal keratinization of hair follicle orifices, etc. Therefore, it is necessary to treat acne with a combination of other medications, rather than using antibiotics alone.