P53 positivity suggests that the tumor is highly malignant and prone to metastasis. P53 is a kind of oncogene in human body, which can make tumor cells apoptosis and prevent cancerous transformation. the half-life of P53 protein encoded by P53 gene is very short, only a few minutes, so it is difficult to be detected. positive P53 protein often indicates that there is a mutation in P53 gene, which is usually related to breast tumors, gastrointestinal tract tumors and hepatocellular tumors, etc. P53 protein correlates with the degree of malignancy of tumor. P53 protein correlates with the malignancy of the tumor, and a positive result indicates that the tumor is highly malignant and prone to invasion and metastasis, resulting in a relatively short survival and poor prognosis for the patient. On the contrary, if P53 is negative, the prognosis of the tumor is relatively good. In the clinic, the survival and treatment effect of patients cannot be determined only by P53 protein, and tumor treatment is a process of comprehensive treatment. It is recommended that patients find P53-positive promptly consult a doctor for a clear diagnosis to determine the treatment plan.