Carotid plaque may become smaller after rupture and dislodgement, and may solidify and shrink after regular medication, but will not disappear. Arterial plaque formation is associated with age, dyslipidemia, hypertension, diabetes, smoking and many other factors, which can cause damage to the endothelial cells of the blood vessels, and lipid components, such as low-density lipoproteins, enter the body under the endothelium of the arteries, leading to atherosclerosis, which in turn triggers the formation of plaque. If an arterial plaque occurs in the carotid artery, it is called a carotid plaque. If the carotid plaque is unstable, it may rupture, fall off, etc., and thus the plaque may become smaller; if it is a stable plaque, and if regular plaque-stabilizing medications such as atorvastatin are given and risk factors are controlled, the plaque may solidify and shrink, and may become slightly smaller, but it will not disappear. Atherosclerotic plaque formation is the main cause of ischemic cerebrovascular disease, therefore, when carotid plaque is detected, it is recommended to consult a doctor in time for early intervention and treatment.