Low serum gastrin is commonly seen in patients with atrophic gastritis, and treatment needs to be determined according to the patient’s condition. When the patient suffers from gastric distension and indigestion, he can be treated with compound digestive enzyme, which is a digestive aid and can facilitate the digestion of food in the stomach. When patients have gastric insufficiency, they can use mosapride to improve, which can promote the recovery of gastrointestinal power and also inhibit nausea and vomiting. Some patients will show excessive secretion of gastric acid and stomach pain, which need to be treated with lansoprazole and colloidal bismuth pectin, which can inhibit gastric acid secretion while promoting the repair of gastric mucosa. Some people suffer from atrophic gastritis due to Helicobacter pylori infection, which requires antibiotics for radical treatment, and two antibiotics, amoxicillin and clarithromycin, can be chosen. Low serum gastrin is also related to gastric cancer, so gastroscopy should be performed to confirm the diagnosis. For patients who are diagnosed with gastric cancer, they should undergo surgery as soon as possible, and after surgery, they should decide whether to undergo radiotherapy or chemotherapy according to the postoperative condition.