Diclofenac sodium suppositories are mainly used for the treatment of rheumatoid arthritis, fever from various causes and pain after surgery. The drug has side effects, which mainly include gastrointestinal reactions, neurological discomfort, and kidney abnormalities. Diclofenac sodium suppository is an anti-inflammatory and analgesic drug, which can inhibit the activity of cyclooxygenase and reduce the synthesis of prostaglandins, thus exerting the effects of antipyretic, anti-inflammatory and analgesic, and is mostly used for the treatment of the above mentioned diseases in clinical practice. The drug needs to be moistened with a small amount of warm water before use, and then gently inserted into the anus 2cm can be. The adverse reactions of the drug mainly include gastrointestinal reactions (such as anal irritation, nausea, heartburn, acid reflux, etc.), neurological discomforts (such as headache, dizziness, drowsiness, etc.), renal abnormalities (such as oliguria, electrolyte disorders, etc.), jaundice, skin rash, etc. If the patient develops any serious discomforts after the use of the drug, it is recommended that the patient seek medical treatment in time. It should be noted that the use of diclofenac sodium suppositories is prohibited in patients who are allergic to any component of the drug, patients with active or previously recurrent peptic ulcers/bleeding, patients with severe heart failure, patients with a history of serious adverse reactions after the application of non-steroidal anti-inflammatory drugs, and patients with perioperative pain during coronary artery bypass grafting surgeries are not allowed to use this drug for treatment. Patients should follow the doctor’s instructions to use diclofenac sodium suppositories, not blindly use their own medication, so as not to induce side effects or affect the condition.