Botulinum toxin can be used for the treatment of hand sweating. The cause of hand sweating is not fully understood and is considered to be related to factors such as genetics and cholinergic sympathetic overactivation. Some patients present with hand sweating, which may be due to secondary factors. It is mainly characterized by increased sweating in the palms of the hands, head and face, armpits and soles of the feet, which may cause a lot of inconvenience in life, work and study. If it has already affected the quality of life, or if there is a need for treatment, it is recommended to visit a hospital dermatologist. There are more treatment options for hand sweating, for example, by local injection of botulinum toxin type A, which can block the release of acetylcholine from cholinergic neurons, which can inhibit sweat gland activity and reduce sweating. In addition to this, topical application of medications such as alum solution and formaldehyde solution can also be used to block the sweat gland orifices and reduce sweat outflow. In addition to this, the administration of anticholinergic drugs, such as oxybutynin, griseofulvin, or treatment through iontophoresis, endoscopic thoracic sympathectomy, etc., can help improve the patient’s symptoms. In summary, hand sweating symptoms are less obvious and usually do not require medical attention. If the symptoms are obvious or there is a need for treatment, you can go to the dermatology department of the hospital for examination and treatment in conjunction with the doctor’s advice.