Abnormal MRI signal of the spleen is usually a descriptor of an imaging test. The abnormal signal may be a cyst or tumor, etc., which requires prompt medical treatment once detected. Splenic cyst is a verrucous cystic lesion of the splenic tissue, which is usually caused by inflammation, splenic trauma, splenic infarction, or parasitic infection, etc. Its symptoms may be manifested as constipation, discomfort in the left upper abdomen, and dyspepsia. Abnormal spleen MRI signals may be caused by tumors, such as hemangiomas and lymphomas, etc. The most common type of hemangioma is a vascular malformation that occurs in vascular tissues, which is benign and slow-growing. Although MRI is the primary test used to diagnose hepatobiliary, pancreatic, and splenic diseases, it should be used in conjunction with other tests to make a comprehensive judgment.