Cold knee pain should be treated with general therapy, medication, physical therapy and surgery according to the cause, considering that it is caused by physiological reasons, osteoarthritis, synovitis and so on. 1. Physiological reasons: Due to poor blood circulation in the knee area and the shallow position of the knee joint, if the temperature of the external environment is too low, it will affect the blood circulation of the joint and cause pain. At this time, you need to pay attention to joint warmth, add appropriate clothing, avoid cold stimulation, you can also apply hot compresses, generally effective in relieving pain. 2. Osteoarthritis: Osteoarthritis is caused by degenerative joint disease, there will be degenerative damage to the joint cartilage, after the cold will aggravate joint inflammation and cause knee pain. Usually pay attention to joint warmth, avoid cold and damp stimulation. Non-steroidal anti-inflammatory drugs, such as celecoxib, can be applied to the treatment. Can also be combined with hot compresses, microwave and other treatments. In the late stage of the development of the disease, the feasibility of artificial joint replacement and other methods of treatment. 3. Synovitis: Various causes of synovial membrane damage, such as trauma, joint degeneration, etc., will cause inflammation of the synovial membrane, which can also cause pain after getting cold. Usually pay attention to rest, can apply celecoxib and other anti-inflammatory pain. It can also be combined with cold compresses, hot compresses, baked electricity and other treatments, and it is also necessary to treat the primary diseases that cause synovitis. There are many other causes of cold knee pain, such as trauma, lower extremity vascular disease and lumbar spine disease, etc. If you continue to have no relief, you should go to the hospital in time for further examination to clarify the cause of the disease and then follow the doctor’s instructions for targeted treatment. The above drugs need to be applied under the guidance of a physician, avoid self-medication.