When hypertension is accompanied by renal insufficiency, the first choice of antihypertensive drugs is Irbesartan or Enalapril, plus diuretics, such as hydrochlorothiazide and furosemide. Because hypertension with renal insufficiency is often accompanied by water and sodium retention, diuretics must be the first choice. Diuretics can filter out excess water, and also have a synergistic effect with other antihypertensive drugs, which means that they can enhance the antihypertensive effect of other antihypertensive drugs. Priligy or sartan antihypertensive drugs have a reversal effect on renal insufficiency and can reduce urinary protein and renin-angiotensin-aldosterone system, so these two drugs are preferred for patients with hypertension accompanied by renal insufficiency.