At what age do epiphyses usually close?

Epiphyseal closure occurs around the age of 18 to 20 years in males and around the age of 16 to 18 years in females. Bone growth and development is generally divided into two types: membranous and chondrogenic bone. In the case of chondrogenic bone, during the embryonic period, mesenchymal cells differentiate into osteoblasts and osteoclasts and begin to make bone, which is the point of primary ossification. Around the birth of the fetus, secondary ossification points appear in the epiphysis, and bone production begins in the epiphysis. The periosteum, primary and secondary ossification points continue to make bone, forming the diaphysis and epiphysis, with epiphyseal cartilage between them. The epiphyseal cartilage continues to grow and ossify, lengthening the bone. As age approaches adulthood, the epiphyseal cartilage stops growing and all ossification closes. The closure of the epiphysis means that the individual loses the potential to grow naturally and the individual’s height is basically set. During the growth spurt, there is localized inflammation due to violent injuries, localized infections such as acute septic osteomyelitis or intra-articular infections. Premature epiphyseal closure can also occur as a result of overexertion or periphyseal inflammation due to excessive compression of the periphyseal bone. When abnormal epiphyseal closure occurs, it is recommended to go to the hospital for examination and treatment.