The main drugs used to relieve premature ejaculation include 5-hydroxytryptamine reuptake inhibitors (SSRIs), phosphodiesterase type 5 inhibitors (PDE5i), local anesthetics, antidepressants, and Chinese herbal medicines. Representative drugs of SSRIs include paroxetine and dapoxetine hydrochloride. They can be taken on an as-needed basis and regular desensitization therapy. The commonly used drug dapoxetine hydrochloride is mainly taken on demand, and due to its short drug half-life, it is more appropriate to be taken orally before sexual intercourse. Most patients can achieve delayed intercourse and improved sexual satisfaction after oral dapoxetine hydrochloride. However, dapoxetine hydrochloride also has side effects such as drug dose dependence, dizziness, nausea, and inability to ejaculate. Paroxetine and sertraline can also be taken regularly to achieve delayed ejaculation. Topical local anesthetics such as lidocaine syrup and benzocaine condoms can reduce sensitivity and treat symptoms of premature ejaculation. pDE5i can also achieve prolonged intercourse in some people. Chinese medicines such as compound Xuanju capsule and Jinliao Gujing pill can also be used under the guidance of Chinese medicine practitioners to treat premature ejaculation symptoms. In summary, premature ejaculation relief drugs mainly include western and proprietary Chinese medicines, representative drugs include dapoxetine hydrochloride, topical lidocaine gel syrup, Jinlock Good Essence Pill, etc., must be used under the guidance of a physician.