When fever with cold hands and feet, it is mostly seen in fever caused by wind-cold bundle surface evidence, which belongs to the cold evidence, and can be added or reduced by Jingfu Dapiao Tang or Jingfu Shengtu San, which has the efficacy of pungent warmth to resolve the surface. If the cold and dampness is heavy, with symptoms such as limb aches and pains, head heaviness and distension, and the body temperature is not high, Qiangwu and Duhong can be added to dispel wind and dampness, and Qiangwu Shengxu Tang can be used to add and subtract. If the hands and feet are hot when having fever, it is mostly due to wind-heat violating the surface, which belongs to the heat evidence, and can use Yin Qiao San with addition and subtraction, which has the efficacy of pungent and cool to relieve the surface. If the fever is more serious, accompanied by thirst, yellow urine and other symptoms, you can add gypsum to clear lung heat. If the throat is sore, you can add Banlangen, Tuoxia, Xuan Shen to clear heat and detoxify the throat. If it is influenza, with severe fever and cold, accompanied by sore throat and cough, add Da Qing Ye, Dandelion, Cao He Che to clear heat and detoxify the toxin. If there are symptoms of mixed cold and heat, you can use Ma Xing Shi Gan Tang plus subtractions, which has the effect of relieving the surface and clearing the interior, relieving cough and resolving phlegm.