Gout is a chronic metabolic disease of the whole body, caused by abnormal purine metabolism in the body, resulting in high levels of uric acid, a purine metabolite in the blood. The best way to prevent gout is to check the blood uric acid concentration regularly (once every 3 months), once the blood uric acid exceeds the normal value, you should take uric acid-lowering drugs, as long as the control of hyperuricemia, gout will not occur. The general principles of gout treatment are: 1) reasonable control of diet; 2) adequate water intake; 3) regular life; 4) appropriate participation in physical activities; 5) effective medication; and 6) regular health checkups. In order to prevent and treat gout, the diet should be three more and three less: l) drink more water, less soup. People with high blood uric acid and gout patients should drink more plain water, less meat soup, fish soup, chicken soup, hot pot soup, etc.. The osmotic pressure of plain water is most conducive to dissolving various harmful substances in the body. Drinking more plain water can dilute uric acid, accelerate excretion, so that the level of uric acid down. The soup contains a lot of purine components, after drinking not only can not dilute uric acid, but also lead to the increase of uric acid. 2) Eat more alkaline food, eat less acidic food. Gout patients themselves have purine metabolism disorders, abnormal uric acid, if too much acidic food, will aggravate the disease, is not conducive to recovery. The actual fact is that you can get a lot of alkaline food to help replenish potassium, sodium and chloride ions and maintain acid-base balance. 3) Eat more vegetables and less meals. Eat more vegetables, help to reduce purine intake, increase vitamin C, increase fiber. Less eating is good for controlling calorie intake, limiting weight, losing weight and lowering fat. Patients with acute gouty arthritis attack should avoid high purine food, such as: yeast, pancreas, concentrated gravy, dried meat, sardines, anchovies, animal heart, etc.. You can eat grapes, oranges, hawthorn, tomatoes, apples, coffee, tea, milk, eggs, seaweed and other low-purine alkaline foods. Do not drink beer Anti-inflammatory drug treatment during acute attacks mainly applies non-steroidal anti-inflammatory drugs (NSAID) to eliminate inflammation and relieve pain, there are many kinds of such drugs, including indomethacin (anti-inflammatory pain), diclofenac sodium (Intravenous, Fotarine), ibuprofen (Fenbid), meloxicam (Mupiaco), etc. Adverse reactions to the gastrointestinal tract reactions are most common, the milder abdominal pain, nausea, vomiting, the more serious The most common adverse reactions are gastrointestinal reactions, such as abdominal pain, nausea and vomiting in mild cases, but in severe cases, they can cause gastric and duodenal ulcers and even complications of gastrointestinal bleeding. In case of pre-existing gastrointestinal diseases, gastric mucosal protective agents, such as omeprazole, ranitidine or misoprostol, should be added at the same time. Generally speaking, the short-term application of therapeutic doses of NSAID will not cause nephropathy, but if long-term high-dose use can lead to chronic interstitial nephritis until chronic renal insufficiency, so once the inflammation subsides and pain is relieved, the drug should be discontinued. More care should be taken if the patient is older, has poor renal function, or has a combination of congestive heart failure, cirrhosis, or other diseases. In addition, NSAID can also cause adverse reactions such as transient transaminase elevation, allergic rash, leukopenia, and headache and tinnitus, so once the drug is started, regular blood and urine tests and liver and kidney functions should be performed to detect and stop the drug as early as possible. Be careful never to combine two NSAIDs or use them simultaneously with corticosteroids. In some patients, because of the poor effect of NSAID, colchicine is applied within the first few hours of the acute attack, and the efficiency can reach more than 90%, which is known as the special drug for gout. However, colchicine is more toxic and the therapeutic dose is close to the dose of gastrointestinal toxicity, so it is usually not used as the drug of choice for acute attacks. In addition, long-term use of colchicine can cause bone marrow suppression and liver and kidney damage, therefore, blood routine, liver and kidney function should be reviewed regularly during the treatment process, and once adverse reactions occur, the drug should be stopped immediately. There are two types of intermittent uric acid-lowering drug therapy. One is the drugs that promote uric acid excretion, such as propofol, sulfopirone and benzbromarone (Ligurian), which have mild adverse effects and no significant effect on liver and kidney function. Patients should drink more water during the course of taking the drug to ensure that the daily urine volume is above 2 liters to facilitate the dissolution and excretion of uric acid. The mechanism of action is to inhibit the synthesis of uric acid. In general, allopurinol is well tolerated by patients, but in patients with renal insufficiency, the side effects of the drug increase significantly, mainly manifesting as skin rash, liver and kidney damage and leukopenia. Since rashes caused by allopurinol are often severe, recurrent and have a high mortality rate, the drug should be discontinued as soon as the rash appears and a full dose of corticosteroids should be administered under medical supervision. In conclusion, any kind of uric acid-lowering drugs should be started in small doses to prevent the rapid precipitation and deposition of uric acid crystals in the joints due to excessive dosage, which may trigger an acute attack of arthritis.