Lobar pneumonia infusion for 14 days,,, large shadows in the lungs may empirical anti-infection did not cover the pathogenic bacteria; the presence of drug-resistant bacteria; diagnostic errors, etc., and require further diagnosis and management. 1. Empirical anti-infection did not cover the pathogenic bacteria. There may be special bacteria such as Pseudomonas aeruginosa, or special pathogens such as Mycoplasma, Chlamydia, or Legionella. If this is the case, it is necessary to change to other broad-spectrum antibiotics such as levofloxacin, and wait for the results of drug sensitivity to target the use of drugs. 2. Drug resistance. If there are still large shadows in the lungs after 14 days of treatment, it is necessary to repeat the drug sensitivity test several times to see if there is drug resistance, and if so, it is necessary to change the sensitive antibiotics such as imipenem in a timely manner. 3. Wrong diagnosis. It is possible that the cause of the large inflammatory shadow is not due to bacteria, but may be viral, immune or even lung cancer, in which case antibiotic treatment is ineffective and further examination is needed. When the treatment is not effective, it is necessary to consult a specialist and adjust the treatment in time, so as to avoid delaying the disease.